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Constraints of Viral RNA Synthesis on Codon Usage of Negative-Strand RNA Virus

7 Dec 2018

Abstract excerpt

Negative-strand RNA viruses (NSVs) include the most pathogenic viruses known. New methods to monitor their evolutionary trends are urgently needed for the development of antivirals and vaccines. The protein translation machinery of the host cell is currently recognized as a main genomic regulator of RNA virus evolution, which works especially well for positive-strand RNA viruses. However, this approach fails for...

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PMID: 30541832
DOI: 10.1128/jvi.01775-18

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