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Rheumatoid Arthritis-Associated Autoimmunity Due to Aggregatibacter actinomycetemcomitans and Its Resolution With Antibiotic Therapy

16 Oct 2018

Abstract excerpt

Objective: We describe a 59-year-old man with a diagnosis of anti-citrullinated protein antibody (ACPA)-positive rheumatoid arthritis (RA) who presented for evaluation of refractory RA. He was found to have infective endocarditis due to Aggregatibacter actinomycetemcomitans (Aa), a bacterial species recently linked to RA pathogenesis. Following antibiotic therapy, joint symptoms resolved and ACPAs normalized....

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Identifiers

PMID: 30459755
DOI: 10.3389/fimmu.2018.02352

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