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Article

RET rearrangements are actionable alterations in breast cancer

12 Nov 2018

Abstract excerpt

Fusions involving the oncogenic gene RET have been observed in thyroid and lung cancers. Here we report RET gene alterations, including amplification, missense mutations, known fusions, novel fusions, and rearrangements in breast cancer. Their frequency, oncogenic potential, and actionability in breast cancer are described. Two out of eight RET fusions (NCOA4-RET and a novel RASGEF1A-RET fusion) and RET...

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Identifiers

PMID: 30446652
DOI: 10.1038/s41467-018-07341-4

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