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Article

Mast cell chymase impairs bronchial epithelium integrity by degrading cell junction molecules of epithelial cells

14 Nov 2018

Abstract excerpt

BACKGROUND: An increased degree of mast cell (MC) degranulation and damage to the epithelial lining are prominent features of bronchial asthma. In asthmatic airways, it seems likely that epithelial cells will be exposed to increased concentrations of proteases from MC, though their actions on the epithelium are still not very clear. METHODS: Bronchial rings from human lung tissue or 16HBE cell monolayer were...

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PMID: 30428129
DOI: 10.1111/all.13666

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