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Article

SGLT2 inhibition and renal urate excretion: role of luminal glucose, GLUT9, and URAT1.

American journal of physiology. Renal physiology - 1 Jan 2019

Novikov Aleksandra, Fu Yiling, Huang Winnie, Freeman Brent, Patel Rohit, van Ginkel Charlotte, Koepsell Hermann, Busslinger Meinrad, Onishi Akira, Nespoux Josselin, Vallon Volker

Abstract excerpt

Inhibitors of the Na+-glucose cotransporter SGLT2 enhance urinary glucose and urate excretion and lower plasma urate levels. The mechanisms remain unclear, but a role for enhanced glucose in the tubular fluid, which may interact with tubular urate transporters, such as the glucose transporter GLUT9 or the urate transporter URAT1, has been proposed. Studies were performed in nondiabetic mice treated with the SGLT2...

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Identifiers

PMID: 30427222
DOI: 10.1152/ajprenal.00462.2018
PMCID: PMC6383194

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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