Article
SGLT5 reabsorbs fructose in the kidney but its deficiency paradoxically exacerbates hepatic steatosis induced by fructose.
PloS one - 1 Jan 2013
Fukuzawa Taku, Fukazawa Masanori, Ueda Otoya, Shimada Hideaki, Kito Aki, Kakefuda Mami, Kawase Yosuke, Wada Naoko A, Goto Chisato, Fukushima Naoshi, Jishage Kou-Ichi, Honda Kiyofumi, King George L, Kawabe Yoshiki
Abstract excerpt
Although excessive fructose intake is epidemiologically linked with dyslipidemia, obesity, and diabetes, the mechanisms regulating plasma fructose are not well known. Cells transfected with sodium/glucose cotransporter 5 (SGLT5), which is expressed exclusively in the kidney, transport fructose in vitro; however, the physiological role of this transporter in fructose metabolism remains unclear. To determine...
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