Article
Influence of Familial Renal Glycosuria Due to Mutations in the SLC5A2 Gene on Changes in Glucose Tolerance over Time.
PloS one - 1 Jan 2016
Ottosson-Laakso Emilia, Tuomi Tiinamaija, Forsén Björn, Gullström Monika, Groop Per-Henrik, Groop Leif, Vikman Petter
Abstract excerpt
Familial renal glycosuria is an inherited disorder resulting in glucose excretion in the urine despite normal blood glucose concentrations. It is most commonly due to mutations in the SLC5A2 gene coding for the glucose transporter SGLT2 in the proximal tubule. Several drugs have been introduced as means to lower glucose in patients with type 2 diabetes targeting SGLT2 resulting in renal glycosuria, but no studies...
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