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Autophagy modulates temozolomide-induced cell death in alveolar Rhabdomyosarcoma cells

25 Oct 2018

Abstract excerpt

Rhabdomyosarcoma (RMS) is a muscle-derived tumor. In both pre-clinical and clinical studies Temozolomide (TMZ) has been recently tested against RMS; however, the precise mechanism of action of TMZ in RMS remains unclear. Here we demonstrate that TMZ decreases the cell viability of the RH30 RMS and C2C12 cell line, where cells display evidence of mitochondrial outer membrane permeability. Interestingly, the C2C12...

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PMID: 30416757
DOI: 10.1038/s41420-018-0115-9

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