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Article

Meiotic nondisjunction and sperm aneuploidy in humans

1 Nov 2018

Abstract excerpt

Infertility is relatively common affecting approximately 1-in-6 couples. Although the genetic basis of infertility is increasingly being uncovered, the contribution of male infertility often remains unexplained. The leading cause of pregnancy loss and cognitive impairment in humans is chromosome aneuploidy. Sperm aneuploidy is routinely evaluated by fluorescence in situ hybridization. The majority of studies have...

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PMID: 30390610
DOI: 10.1530/rep-18-0318

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