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Article

Drug resistance evaluation in novel 3D in vitro model

30 Mar 2021

Abstract excerpt

Ovarian cancer rates the highest mortality among all gynecological malignancies. The main reason for high mortality is the development of drug resistance. It can be related to changes in the expression of many drug resistance genes as well as expression of extracellular matrix proteins and cell density in the tumor. We developed a simple two-dimensional and three-dimensional model of drug sensitive A2780 and...

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PMID: 34311534
DOI: 10.1016/j.biopha.2021.111536

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