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Haploid Germ Cells Generated in Organotypic Culture of Testicular Tissue From Prepubertal Boys

9 Oct 2018

Abstract excerpt

While in mice various studies have described the completion of spermatogenesis in vitro using either organotypic culture of prepubertal testicular tissue or 3D culture of isolated cells, in humans it has not been possible to achieve germ cell differentiation from immature testicular tissue (ITT). In our study, we evaluated the ability of human ITT to differentiate via a long-term organotypic culture of...

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PMID: 30356879
DOI: 10.3389/fphys.2018.01413

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