Article
A biobank of patient-derived pediatric brain tumor models.
Nature medicine - 1 Nov 2018
Brabetz Sebastian, Leary Sarah E S, Gröbner Susanne N, Nakamoto Madison W, Şeker-Cin Huriye, Girard Emily J, Cole Bonnie, Strand Andrew D, Bloom Karina L, Hovestadt Volker, Mack Norman L, Pakiam Fiona, Schwalm Benjamin, Korshunov Andrey, Balasubramanian Gnana Prakash, Northcott Paul A, Pedro Kyle D, Dey Joyoti, Hansen Stacey, Ditzler Sally, Lichter Peter, Chavez Lukas, Jones David T W, Koster Jan, Pfister Stefan M, Kool Marcel, Olson James M
Abstract excerpt
Brain tumors are the leading cause of cancer-related death in children. Genomic studies have provided insights into molecular subgroups and oncogenic drivers of pediatric brain tumors that may lead to novel therapeutic strategies. To evaluate new treatments, better preclinical models adequately reflecting the biological heterogeneity are needed. Through the Children's Oncology Group ACNS02B3 study, we have...
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