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Prognostic role of DOK family adapters in acute myeloid leukemia.

Cancer gene therapy - 1 Sept 2019

Zhang Lin, Li Ran, Hu Kai, Dai Yifeng, Pang Yifan, Jiao Yang, Liu Yan, Cui Longzhen, Shi Jinlong, Cheng Zhiheng, Fu Lin

Abstract excerpt

Acute myeloid leukemia (AML) is a genetically and clinically heterogeneous disease. Gene mutational and expressional profile can aid the identification of different prognostic subgroups. Downstream of tyrosine kinase (DOK) proteins are a multigenic family of adaptors; some of them are key negative regulators of immune cell signaling. However, the expression and clinical implication of DOK family in AML has rarely...

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Identifiers

PMID: 30348947
DOI: 10.1038/s41417-018-0052-z

Genes

EFS
DOK5
DOK4
DOK7
DOK1

Provenance

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