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Article

Structural basis for DNA break recognition by ARTD2/PARP2

4 Oct 2018

Abstract excerpt

Human ARTD2 (or PARP2) is an ADP-ribosyltransferase, which is catalytically activated by binding to damaged DNA. ARTD2 subsequently ADP-ribosylates itself and other proteins, initiating a cascade of events leading to DNA repair. In contrast to ARTD1, the founding member of the enzyme family, ARTD2 does not have specialized zinc-fingers for detecting DNA damage. The domain organization of ARTD2 includes disordered...

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PMID: 30321391
DOI: 10.1093/nar/gky927

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