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The Treatment of Activated PI3Kδ Syndrome

7 Sept 2018

Abstract excerpt

Activated phosphoinositide 3-kinase δ syndrome (APDS), also known as PASLI disease (p110d-activating mutation causing senescent T cells, lymphadenopathy, and immunodeficiency) are combined immunodeficiencies resulting from gain-of-function mutations in the genes (PIK3CD and PIK3R1) encoding the subunits of phosphoinositide 3-kinase δ (PI3Kδ) and were first described in 2013. These mutations result in the...

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PMID: 30245694
DOI: 10.3389/fimmu.2018.02043

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