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Pulmonary Metagenomic Sequencing Suggests Missed Infections in Immunocompromised Children

13 Sept 2018

Abstract excerpt

BACKGROUND: Despite improved diagnostics, pulmonary pathogens in immunocompromised children frequently evade detection, leading to significant mortality. Therefore, we aimed to develop a highly sensitive metagenomic next-generation sequencing (mNGS) assay capable of evaluating the pulmonary microbiome and identifying diverse pathogens in the lungs of immunocompromised children. METHODS: We collected 41 lower...

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PMID: 30239621
DOI: 10.1093/cid/ciy802

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