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Chromatin remodeling controls Kaposi's sarcoma-associated herpesvirus reactivation from latency

13 Sept 2018

Abstract excerpt

Kaposi's sarcoma-associated herpesvirus (KSHV) is the etiologic agent of three human malignancies, the endothelial cell cancer Kaposi's sarcoma, and two B cell cancers, Primary Effusion Lymphoma and multicentric Castleman's disease.KSHV has latent and lytic phases of the viral life cycle, and while both contribute to viral pathogenesis, lytic proteins contribute to KSHV-mediated oncogenesis.Reactivation from...

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PMID: 30212584
DOI: 10.1371/journal.ppat.1007267

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