Article
Expression of the human TRIM14 and its mutant form (P207L) promotes apoptosis in transgenic loaches.
Molecular biology reports - 1 Dec 2018
Nenasheva Valentina V, Stepanenko Ekaterina A, Makarova Irina V, Khaidarova Nella V, Antonov Stanislav A, Kozikova Larisa V, Polteva Ekaterina A, Kovaleva Galina V, Ayed Zeineb, Vovk Anastasia D, Shcherbatova Natalya A, Andreeva Lyudmila E, Tarantul Vyacheslav Z
Abstract excerpt
The tripartite-motif (TRIM)14 protein, one of the TRIM family members, was shown to participate in the antiviral and antibacterial defence. Besides, it appears to play an essential role in the processes of oncogenesis. In some types of human tumour cells, TRIM14 has been shown to inhibit apoptosis, while in others-the overexpression of TRIM14 promotes apoptosis. However, whether TRIM14 mediates apoptosis in the...
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