Article
Children with Neutrophil-Predominant Severe Asthma Have Proinflammatory Neutrophils With Enhanced Survival and Impaired Clearance.
The journal of allergy and clinical immunology. In practice - 1 Feb 2019
Grunwell Jocelyn R, Stephenson Susan T, Tirouvanziam Rabindra, Brown Lou Ann S, Brown Milton R, Fitzpatrick Anne M
Abstract excerpt
BACKGROUND: Airway neutrophils are abundant in some children with severe asthma, but their functions are poorly understood. OBJECTIVE: To characterize that the inflammatory airway environment of children with neutrophil-predominant severe asthma promotes neutrophil survival and disrupts neutrophil-associated innate immune defenses. METHODS: Sixty-seven children with severe asthma refractory to high-dose inhaled...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.