Article
Childhood asthma clusters reveal neutrophil-predominant phenotype with distinct gene expression.
Allergy - 1 Oct 2018
Su M-W, Lin W-C, Tsai C-H, Chiang B-L, Yang Y-H, Lin Y-T, Wang L-C, Lee J-H, Chou C-C, Wu Y-F, Yeh Y-L, Lee Y L
Abstract excerpt
BACKGROUND: Childhood asthma comprises different phenotypes with complex pathophysiology. Different asthma phenotypes evoke various clinical symptoms and vary in their responses to treatments. METHODS: We applied k-means clustering algorithm of twelve objective laboratory tests among 351 asthmatic children enrolled in the Taiwanese Consortium of Childhood Asthma Study (TCCAS). We constructed gene expression...
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