Article
Lysosomes nor Mice Move Forward without Borcs7.
Trends in cell biology - 1 Oct 2018
Joshi Urjita, Houwman Joseline A, van der Sluijs Peter
Abstract excerpt
Lysosome function and position in the cytoplasm depends on the BORCS machinery, which tethers lysosomes to the kinesin microtubule motor. A recent paper of Snouwaert et al. in Cell Reports characterizes a mouse with a spontaneous mutation in the Borcs7 subunit, which causes axonal dystrophy and impaired motor function.
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