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Microsatellite instability in gastric cancer: molecular bases, clinical perspectives, and new treatment approaches

1 Sept 2018

Abstract excerpt

Gastric cancer is one of the most aggressive malignancies, with limited treatment options in both locally advanced and metastatic setting, resulting in poor prognosis. Based on genomic characterization, stomach tumour has recently been described as a heterogeneous disease composed by different subtypes, each of them with peculiar molecular aspects and specific clinical behaviour. With an incidence of 22% among...

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PMID: 30173350
DOI: 10.1007/s00018-018-2906-9

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