Article
Linking the heart and the brain: Neurodevelopmental disorders in patients with catecholaminergic polymorphic ventricular tachycardia.
Heart rhythm - 1 Feb 2019
Lieve Krystien V V, Verhagen Judith M A, Wei Jinhong, Bos J Martijn, van der Werf Christian, Rosés I Noguer Ferran, Mancini Grazia M S, Guo Wenting, Wang Ruiwu, van den Heuvel Freek, Frohn-Mulder Ingrid M E, Shimizu Wataru, Nogami Akihiko, Horigome Hitoshi, Roberts Jason D, Leenhardt Antoine, Crijns Harry J G, Blank Andreas C, Aiba Takeshi, Wiesfeld Ans C P, Blom Nico A, Sumitomo Naokata, Till Jan, Ackerman Michael J, Chen S R Wayne, van de Laar Ingrid M B H, Wilde Arthur A M
Abstract excerpt
BACKGROUND: Catecholaminergic polymorphic ventricular tachycardia (CPVT) is an uncommon inherited arrhythmia disorder characterized by adrenergically evoked ventricular arrhythmias. Mutations in the cardiac calcium release channel/ryanodine receptor gene (RYR2) are identified in the majority of patients with CPVT. RyR2 is also the major RyR isoform expressed in the brain. OBJECTIVE: The purpose of this study was...
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