Article
Intellectual and Neurodevelopmental Delays in Pediatric Catecholaminergic Polymorphic Ventricular Tachycardia: Distinct Characteristics and a More Malignant Neurocardiac Phenotype.
Circulation. Arrhythmia and electrophysiology - 1 Oct 2025
Miyake Christina Y, Kallas Dania, Stephens Sara B, Moore Oliver M, Wehrens Xander H T, Fischbach Peter S, LaPage Martin J, Landstrom Andrew P, Law Ian H, Hill Allison C, Kannankeril Prince J, Fish Frank A, Howard Taylor S, Valdes Santiago O, Pham Tam Dan N, Kim Jeffrey J, Dhillon Santokh S, Johnsrude Christopher L, Krause Ulrich, Sarquella-Brugada Georgia, Kubuš Peter, Tavacova Terezia, Kwok Sit-Yee, Etheridge Susan P, Tisma-Dupanovic Svjetlana, Kean Adam C, Krahn Andrew D, Ebrahim Mohammed A, Atallah Joseph, Fournier Anne, Batra Anjan S, Young Ming-Lon, Perry James, Kovach Joshua R, Kamp Anna N, Clark Bradley C, Jimenez Erick, Charafeddine Fatme, Hamilton Robert M, Balaji Seshadri, Sanatani Shubhayan
Abstract excerpt
BACKGROUND: Marked intellectual and neurodevelopmental delay (INDD) was noted in 6 unrelated patients diagnosed with RYR2-related catecholaminergic polymorphic ventricular tachycardia (CPVT) from a single center. Patients exhibited similar distinct phenotypic features not previously described. We aimed to determine the prevalence of INDD in CPVT, compare clinical characteristics between patients with CPVT with...
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