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Article

Neurocardiogenetics: Exploring the association of rare RYR2 variants with neuropsychiatric disorders in general and disease populations.

Journal of neurogenetics - 1 Jan 2026

Dababneh Saif F, Roberts Jason D, Tan Sixuan, Wei Jinhong, Wang Ruiwu, Estillore John Paul, Kallas Dania, Tibbits Glen F, Sanatani Shubhayan, Chen S R Wayne, Roston Thomas M

Abstract excerpt

Overlapping neuropsychiatric and cardiac features in rare monogenic syndromes stem from shared gene expression. Pathogenic gain-of-function RYR2 variants, leading to a lethal cardiac arrhythmia syndrome known as catecholaminergic polymorphic ventricular tachycardia (CPVT), have also been associated with neuropsychiatric disorders such as epilepsy, schizophrenia, and intellectual disability. Neuropsychiatric...

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Share to Arrhythmias, Cardiac
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Polymorphic Catecholaminergic Ventricular Tachycardia

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Source

Identifiers

PMID: 41746136
DOI: 10.1080/01677063.2026.2632080

Genes

RYR2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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Neurocardiogenetics: Exploring the association of rare RYR2 variants with neuropsychiatric disorders in general and disease populations.PMID 41746136Read ↗

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