Article
MHC-II Deficiency Among Egyptians: Novel Mutations and Unique Phenotypes.
The journal of allergy and clinical immunology. In practice - 1 Mar 2019
El Hawary Rabab E, Mauracher Andrea A, Meshaal Safa S, Eldash Alia, Abd Elaziz Dalia S, Alkady Radwa, Lotfy Sohilla, Opitz Lennart, Galal Nermeen M, Boutros Jeannette A, Pachlopnik Schmid Jana, Elmarsafy Aisha M
Abstract excerpt
BACKGROUND: MHC class II deficiency leads to defective CD4+ T-cell function that results from impaired antigen presentation. A genetic disorder in 1 of 4 genes results in this syndrome that is associated with the clinical phenotype of combined immunodeficiency. OBJECTIVE: To describe the clinical, immunological, and molecular characteristics of 10 Egyptian patients from 9 different families having presented with...
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