Article
Clinical, Immunological, and Molecular Findings in Five Patients with Major Histocompatibility Complex Class II Deficiency from India.
Frontiers in immunology - 1 Jan 2018
Aluri Jahnavi, Gupta Maya, Dalvi Aparna, Mhatre Snehal, Kulkarni Manasi, Hule Gouri, Desai Mukesh, Shah Nitin, Taur Prasad, Vedam Ramprasad, Madkaikar Manisha
Abstract excerpt
Major histocompatibility complex (MHC) class II deficiency is a rare autosomal recessive form of primary immunodeficiency disorder (PID) characterized by the deficiency of MHC class II molecules. This deficiency affects the cellular and humoral immune response by impairing the development of CD4+ T helper (Th) cells and Th cell-dependent antibody production by B cells. Affected children typically present with...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.