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Article

PTTG and PBF Functionally Interact with p53 and Predict Overall Survival in Head and Neck Cancer.

Cancer research - 15 Oct 2018

Read Martin L, Modasia Bhavika, Fletcher Alice, Thompson Rebecca J, Brookes Katie, Rae Peter C, Nieto Hannah R, Poole Vikki L, Roberts Sally, Campbell Moray J, Boelaert Kristien, Turnell Andrew S, Smith Vicki E, Mehanna Hisham, McCabe Christopher J

Abstract excerpt

Head and neck squamous cell carcinoma (HNSCC) is the 6th most common cancer worldwide and poses a significant health burden due to its rising incidence. Although the proto-oncogene pituitary tumor-transforming gene 1 (PTTG) predicts poor patient outcome, its mechanisms of action are incompletely understood. We show here that the protein PBF modulates PTTG function, is overexpressed in HNSCC tumors, and correlates...

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Identifiers

PMID: 30154144
DOI: 10.1158/0008-5472.CAN-18-0855
PMCID: PMC6193540

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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