Article
Functional consequences of the first reported mutations of the proto-oncogene PTTG1IP/PBF.
Endocrine-related cancer - 1 Sept 2017
Imruetaicharoenchoke W, Fletcher A, Lu W, Watkins R J, Modasia B, Poole V L, Nieto H R, Thompson R J, Boelaert K, Read M L, Smith V E, McCabe C J
Abstract excerpt
Pituitary tumor-transforming gene 1-binding factor (PTTG1IP; PBF) is a multifunctional glycoprotein, which is overexpressed in a wide range of tumours, and significantly associated with poorer oncological outcomes, such as early tumour recurrence, distant metastasis, extramural vascular invasion and decreased disease-specific survival. PBF transforms NIH 3T3 fibroblasts and induces tumours in nude mice, while...
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