Article
Analysis ofMDM2Amplification: Next-Generation Sequencing of Patients With Diverse Malignancies
13 Jul 2018
Abstract excerpt
Purpose MDM2 amplification can promote tumorigenesis directly or indirectly through p53 inhibition. MDM2 has increasing clinical relevance because inhibitors are under evaluation in clinical trials, and MDM2 amplification is a possible genomic correlate of accelerated progression, known as hyperprogression, after anti–PD-1/PD-L1 immunotherapy. We used next-generation sequencing (NGS) to ascertain MDM2...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.