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Article

Tumor Antigen Escape from CAR T-cell Therapy

22 Aug 2018

Abstract excerpt

Abstract Emerging data from chimeric antigen receptor (CAR) T-cell trials in B-cell malignancies demonstrate that a common mechanism of resistance to this novel class of therapeutics is the emergence of tumors with loss or downregulation of the target antigen. Antigen loss or antigen-low escape is likely to emerge as an even greater barrier to success in solid tumors, which manifest greater heterogeneity in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 30135176
DOI: 10.1158/2159-8290.cd-18-0442

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