Article
Trans-heterozygosity for mutations enhances the risk of recurrent/chronic pancreatitis in patients with Cystic Fibrosis.
Molecular medicine (Cambridge, Mass.) - 27 Jul 2018
Sofia Valentina Maria, Surace Cecilia, Terlizzi Vito, Da Sacco Letizia, Alghisi Federico, Angiolillo Antonella, Braggion Cesare, Cirilli Natalia, Colombo Carla, Di Lullo Antonella, Padoan Rita, Quattrucci Serena, Raia Valeria, Tuccio Giuseppe, Zarrilli Federica, Tomaiuolo Anna Cristina, Novelli Antonio, Lucidi Vincenzina, Lucarelli Marco, Castaldo Giuseppe, Angioni Adriano
Abstract excerpt
BACKGROUND: Recurrent (RP) and chronic pancreatitis (CP) may complicate Cystic Fibrosis (CF). It is still unknown if mutations in genes involved in the intrapancreatic activation of trypsin (IPAT) or in the pancreatic secretion pathway (PSP) may enhance the risk for RP/CP in patients with CF. METHODS: We enrolled: 48 patients affected by CF complicated by RP/CP and, as controls 35 patients with CF without...
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