Article
Promoter expression of HERV-K (HML-2) provirus-derived sequences is related to LTR sequence variation and polymorphic transcription factor binding sites.
Retrovirology - 20 Aug 2018
Montesion Meagan, Williams Zachary H, Subramanian Ravi P, Kuperwasser Charlotte, Coffin John M
Abstract excerpt
BACKGROUND: Increased transcription of the human endogenous retrovirus group HERV-K (HML-2) is often seen during disease. Although the mechanism of its tissue-specific activation is unclear, research shows that LTR CpG hypomethylation alone is not sufficient to induce its promoter activity and that the transcriptional milieu of a malignant cell contributes, at least partly, to differential HML-2 expression....
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