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The distribution of insertionally polymorphic endogenous retroviruses in breast cancer patients and cancer-free controls

11 Aug 2014

Abstract excerpt

BACKGROUND: Integration of retroviral DNA into a germ cell can result in a provirus that is transmitted vertically to the host's offspring. In humans, such endogenous retroviruses (HERVs) comprise >8% of the genome. The HERV-K(HML-2) proviruses consist of ~90 elements related to mouse mammary tumor virus, which causes breast cancer in mice. A subset of HERV-K(HML-2) proviruses has some or all genes intact, and...

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PMID: 25112280
DOI: 10.1186/s12977-014-0062-3

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