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Phytochemicals, withaferin A and carnosol, overcome pancreatic cancer stem cells as c-Met inhibitors.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie - 1 Oct 2018

Aliebrahimi Shima, Kouhsari Shideh Montasser, Arab Seyed Shahriar, Shadboorestan Amir, Ostad Seyed Nasser

Abstract excerpt

Receptor tyrosine kinases (RTKs) are pharmaceutically attractive targets due to their fundamental role in tumor formation. The hallmark of pancreatic cancer is its high mortality rate attributed to the existence of cancer stem cell (CSC) subpopulations which result in therapy resistance and recurrence. c-Met is a known pancreatic CSC marker that belongs to the family of RTKs. To surmount the hurdles related to...

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PMID: 30119228
DOI: 10.1016/j.biopha.2018.07.055

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HGF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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