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Article

Identifying mixed Mycobacterium tuberculosis infections from whole genome sequence data.

BMC genomics - 14 Aug 2018

Sobkowiak Benjamin, Glynn Judith R, Houben Rein M G J, Mallard Kim, Phelan Jody E, Guerra-Assunção José Afonso, Banda Louis, Mzembe Themba, Viveiros Miguel, McNerney Ruth, Parkhill Julian, Crampin Amelia C, Clark Taane G

Abstract excerpt

BACKGROUND: Mixed, polyclonal Mycobacterium tuberculosis infection occurs in natural populations. Developing an effective method for detecting such cases is important in measuring the success of treatment and reconstruction of transmission between patients. Using whole genome sequence (WGS) data, we assess two methods for detecting mixed infection: (i) a combination of the number of heterozygous sites and the...

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Identifiers

PMID: 30107785
DOI: 10.1186/s12864-018-4988-z
PMCID: PMC6092779

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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