High resolution melting curve analysis enables rapid and reliable detection of G6PD variants in heterozygous females.

doi:10.1186/s12863-018-0664-1

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High resolution melting curve analysis enables rapid and reliable detection of G6PD variants in heterozygous females.

BMC genetics - 10 Aug 2018

Islam Md Tarikul, Sarker Suprovath Kumar, Talukder Shezote, Bhuyan Golam Sarower, Rahat Asifuzzaman, Islam Nafisa Nawal, Mahmud Hasan, Hossain Mohammad Amir, Muraduzzaman A K M, Rahman Jakia, Qadri Syeda Kashfi, Shahidullah Mohammod, Mannan Mohammad Abdul, Tahura Sarabon, Hussain Manzoor, Saha Narayan, Akhter Shahida, Nahar Nazmun, Begum Firoza, Shirin Tahmina, Akhteruzzaman Sharif, Qadri Syed Saleheen, Qadri Firdausi, Mannoor Kaiissar

Abstract excerpt

BACKGROUND: Like glucose-6-phosphate dehydrogenase (G6PD) deficient hemizygous males and homozygous females, heterozygous females could also manifest hemolytic crisis, neonatal hyperbilirubinemia or kernicterus upon exposure to oxidative stress induced by certain foods such as fava beans, drugs or infections. Although hemizygous males and homozygous females are easily detected by conventional G6PD enzyme assay...

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PMID: 30097005
DOI: 10.1186/s12863-018-0664-1
PMCID: PMC6086071

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