Article
Ischemic tau protein gene induction as an additional key factor driving development of Alzheimer's phenotype changes in CA1 area of hippocampus in an ischemic model of Alzheimer's disease.
Pharmacological reports : PR - 1 Oct 2018
Pluta Ryszard, Bogucka-Kocka Anna, Ułamek-Kozioł Marzena, Bogucki Jacek, Januszewski Sławomir, Kocki Janusz, Czuczwar Stanisław J
Abstract excerpt
BACKGROUND: Tauopathies are a class of neurodegenerative illnesses associated with the aberrant accumulation of the tau protein in the brain. The best known out of these diseases is Alzheimer's disease, a disorder where the microtubule associated tau protein becomes hyperphosphorylated (which lowers its binding affinity to microtubules) and accumulates inside neurons in the form of tangles. In this study, we...
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