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Article

Examination of the shared genetic basis of anorexia nervosa and obsessive-compulsive disorder.

Molecular psychiatry - 1 Sept 2020

Yilmaz Zeynep, Halvorsen Matthew, Bryois Julien, Yu Dongmei, Thornton Laura M, Zerwas Stephanie, Micali Nadia, Moessner Rainald, Burton Christie L, Zai Gwyneth, Erdman Lauren, Kas Martien J, Arnold Paul D, Davis Lea K, Knowles James A, Breen Gerome, Scharf Jeremiah M, Nestadt Gerald, Mathews Carol A, Bulik Cynthia M, Mattheisen Manuel, Crowley James J

Abstract excerpt

Anorexia nervosa (AN) and obsessive-compulsive disorder (OCD) are often comorbid and likely to share genetic risk factors. Hence, we examine their shared genetic background using a cross-disorder GWAS meta-analysis of 3495 AN cases, 2688 OCD cases, and 18,013 controls. We confirmed a high genetic correlation between AN and OCD (rg = 0.49 ± 0.13, p = 9.07 × 10-7) and a sizable SNP heritability (SNP...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 30087453
DOI: 10.1038/s41380-018-0115-4
PMCID: PMC6367065

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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