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Article

Critical role of CD4+ T cells and IFNγ signaling in antibody-mediated resistance to Zika virus infection

1 Aug 2018

Abstract excerpt

Abstract Protective adaptive immunity to Zika virus (ZIKV) has been mainly attributed to cytotoxic CD8+ T cells and neutralizing antibodies, while the participation of CD4+ T cells in resistance has remained largely uncharacterized. Here, we show a neutralizing antibody response, dependent on CD4+ T cells and IFNγ signaling, which we detected during the first week of infection and is associated with reduced viral...

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PMID: 30087337
DOI: 10.1038/s41467-018-05519-4

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