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Article

Comparative analysis of virus-host interactions caused by a virulent and an attenuated duck hepatitis A virus genotype 1.

PloS one - 1 Jan 2017

Ou Xumin, Mao Sai, Cao Jingyu, Cheng Anchun, Wang Mingshu, Zhu Dekang, Chen Shun, Jia Renyong, Liu Mafeng, Sun Kunfeng, Yang Qiao, Wu Ying, Chen Xiaoyue

Abstract excerpt

Because of their better immunogenicity and the improved protection they afford, live attenuated vaccines derived from serial passaging in an abnormal host are widely used to protect humans or animals from certain pathogens. Here, we used a virulent and a chicken embryo-attenuated duck hepatitis A virus genotype 1 to compare the different regulated immune responses induced by viruses with differing virulence. In...

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Identifiers

PMID: 28614378
DOI: 10.1371/journal.pone.0178993
PMCID: PMC5470708

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