Clinical Validity of Genes for Heritable Thoracic Aortic Aneurysm and Dissection.

doi:10.1016/j.jacc.2018.04.089

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Clinical Validity of Genes for Heritable Thoracic Aortic Aneurysm and Dissection.

Journal of the American College of Cardiology - 7 Aug 2018

Renard Marjolijn, Francis Catherine, Ghosh Rajarshi, Scott Alan F, Witmer P Dane, Adès Lesley C, Andelfinger Gregor U, Arnaud Pauline, Boileau Catherine, Callewaert Bert L, Guo Dongchuan, Hanna Nadine, Lindsay Mark E, Morisaki Hiroko, Morisaki Takayuki, Pachter Nicholas, Robert Leema, Van Laer Lut, Dietz Harry C, Loeys Bart L, Milewicz Dianna M, De Backer Julie

Abstract excerpt

BACKGROUND: Thoracic aortic aneurysms progressively enlarge and predispose to acute aortic dissections. Up to 25% of individuals with thoracic aortic disease harbor an underlying Mendelian pathogenic variant. An evidence-based strategy for selection of genes to test in hereditary thoracic aortic aneurysm and dissection (HTAAD) helps inform family screening and intervention to prevent life-threatening thoracic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aortic aneurysm repair treatments

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Aortic Aneurysm, Thoracic

Share to Aortic Disease and Treatment Approaches

Share to Aortic Dissection

Share to Connective tissue disorders research

Share to Genetic Predisposition to Disease

Share to Genetic Testing

Share to Reproducibility of Results

Source

Open in PubMed Open full text

Identifiers

PMID: 30071989
DOI: 10.1016/j.jacc.2018.04.089
PMCID: PMC6378369

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Clinical Validity of Genes for Heritable Thoracic Aortic Aneurysm and Dissection.PMID 30071989Read ↗

Update on the genetic risk for thoracic aortic aneurysms and acute aortic dissections: implications for clinical care.Semantic proximity Read ↗

Molecular characterization and clinical investigation of patients with heritable thoracic aortic aneurysm and dissection.Semantic proximity Read ↗

Thoracic aortic aneurysm gene dictionary.Semantic proximity Read ↗

Clinical Interpretation of Genetic Variants in the Evaluation and Management of Thoracic Aortic Aneurysm and Dissection.Semantic proximity Read ↗

Cardiogenetics: genetic testing in the diagnosis and management of patients with aortic disease.Semantic proximity Read ↗

Genes Associated with Thoracic Aortic Aneurysm and Dissection: 2018 Update and Clinical ImplicationsSemantic proximity Read ↗

Comparative Risks of Initial Aortic Events Associated With Genetic Thoracic Aortic Disease.Semantic proximity Read ↗

Insights on Prevalence of Hereditary Aortic Thoracic Disease and Impact on Family Screening in Routine Clinical Cardiothoracic Surgery CareSemantic proximity Read ↗

The Role of Genetic Testing in Patients with Heritable Thoracic Aortic DiseasesSemantic proximity Read ↗

Genome-First Approach to Rare and Common Variant Risk of Thoracic Aortic Aneurysm and DissectionSemantic proximity Read ↗

Utilization of current ACC/AHA genetic testing recommendations for thoracic aortic disease at a large adult aortic center.Semantic proximity Read ↗

Variants of Unknown Significance in Genes Associated with Heritable Thoracic Aortic Disease Can Be Low Penetrant "Risk Variants".Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.