Article
The etiology of multiple sclerosis: genetic evidence for the involvement of the human endogenous retrovirus HERV-Fc1.
PloS one - 2 Feb 2011
Nexø Bjørn A, Christensen Tove, Frederiksen Jette, Møller-Larsen Anné, Oturai Annette B, Villesen Palle, Hansen Bettina, Nissen Kari K, Laska Magdalena J, Petersen Trine S, Bonnesen Sandra, Hedemand Anne, Wu Tingting, Wang Xinjie, Zhang Xiuqing, Brudek Tomasz, Maric Romana, Søndergaard Helle B, Sellebjerg Finn, Brusgaard Klaus, Kjeldbjerg Anders L, Rasmussen Henrik B, Nielsen Anders L, Nyegaard Mette, Petersen Thor, Børglum Anders D, Pedersen Finn S
Abstract excerpt
We have investigated the role of human endogenous retroviruses in multiple sclerosis by analyzing the DNA of patients and controls in 4 cohorts for associations between multiple sclerosis and polymorphisms near viral restriction genes or near endogenous retroviral loci with one or more intact or almost-intact genes. We found that SNPs in the gene TRIM5 were inversely correlated with disease. Conversely, SNPs...
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