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Article

HERV-W polymorphism in chromosome X is associated with multiple sclerosis risk and with differential expression of MSRV.

Retrovirology - 9 Jan 2014

García-Montojo Marta, de la Hera Belén, Varadé Jezabel, de la Encarnación Ana, Camacho Iris, Domínguez-Mozo María, Árias-Leal Ana, García-Martínez Angel, Casanova Ignacio, Izquierdo Guillermo, Lucas Miguel, Fedetz Maria, Alcina Antonio, Arroyo Rafael, Matesanz Fuencisla, Urcelay Elena, Alvarez-Lafuente Roberto

Abstract excerpt

BACKGROUND: Multiple Sclerosis (MS) is an autoimmune demyelinating disease that occurs more frequently in women than in men. Multiple Sclerosis Associated Retrovirus (MSRV) is a member of HERV-W, a multicopy human endogenous retroviral family repeatedly implicated in MS pathogenesis. MSRV envelope protein is elevated in the serum of MS patients and induces inflammation and demyelination but, in spite of this...

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Share to Chromosomal and Genetic Variations
Share to Chromosomes, Human, X

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Endogenous Retroviruses

Share to Genetic Predisposition to Disease

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Share to Multiple Sclerosis Research Studies

Share to Polymorphism, Genetic

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Source

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Identifiers

PMID: 24405691
DOI: 10.1186/1742-4690-11-2
PMCID: PMC3892049

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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