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Article

Tumor Mutation Burden and Efficacy of EGFR-Tyrosine Kinase Inhibitors in Patients with EGFR-Mutant Lung Cancers.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Feb 2019

Offin Michael, Rizvi Hira, Tenet Megan, Ni Andy, Sanchez-Vega Francisco, Li Bob T, Drilon Alexander, Kris Mark G, Rudin Charles M, Schultz Nikolaus, Arcila Maria E, Ladanyi Marc, Riely Gregory J, Yu Helena, Hellmann Matthew D

Abstract excerpt

PURPOSE: Tumor mutation burden (TMB) is a biomarker of response to immune checkpoint blockade (ICB). The impact of TMB on outcomes with targeted therapies has not been explored. EXPERIMENTAL DESIGN: We identified all patients with metastatic EGFR exon19del or L858R-mutant lung cancers treated with first/second-generation EGFR tyrosine kinase inhibitors (TKIs) with pretreatment next-generation sequencing data...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 30045933
DOI: 10.1158/1078-0432.CCR-18-1102
PMCID: PMC6347551

Genes

EGFR
IMPACT

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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