Article
IgA regulates the composition and metabolic function of gut microbiota by promoting symbiosis between bacteria.
The Journal of experimental medicine - 6 Aug 2018
Nakajima Akira, Vogelzang Alexis, Maruya Mikako, Miyajima Michio, Murata Megumi, Son Aoi, Kuwahara Tomomi, Tsuruyama Tatsuaki, Yamada Satoshi, Matsuura Minoru, Nakase Hiroshi, Peterson Daniel A, Fagarasan Sidonia, Suzuki Keiichiro
Abstract excerpt
Immunoglobulin A (IgA) promotes health by regulating the composition and function of gut microbiota, but the molecular requirements for such homeostatic IgA function remain unknown. We found that a heavily glycosylated monoclonal IgA recognizing ovalbumin coats Bacteroides thetaiotaomicron (B. theta), a prominent gut symbiont of the phylum Bacteroidetes. In vivo, IgA alters the expression of polysaccharide...
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