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Article

Modeling three-dimensional genomic organization in evolution and pathogenesis.

Seminars in cell & developmental biology - 1 Jun 2019

Diament Alon, Tuller Tamir

Abstract excerpt

The regulation of gene expression is mediated via the complex three-dimensional (3D) conformation of the genetic material and its interactions with various intracellular factors. Various experimental and computational approaches have been developed in recent years for understating the relation between the 3D conformation of the genome and the phenotypes of cells in normal condition and diseases. In this review,...

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PMID: 30030143
DOI: 10.1016/j.semcdb.2018.07.008

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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