Altered Gene Expression in Prefrontal Cortex of a Fabry Disease Mouse Model

Abstract excerpt

Fabry disease is an X-chromosome linked hereditary disease that is caused by loss of function mutations in the α-galactosidase A (α-Gal A) gene, resulting in defective glycolipid degradation and subsequent accumulation of globotriaosylceramide (Gb3) in different tissues, including vascular endothelial cells and neurons in the peripheral and central nervous system. We recently reported a differential gene...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Lysosomal Storage Disorders Research
• Share to Neuroinflammation and Neurodegeneration Mechanisms
• Share to Neurological diseases and metabolism