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Article

Association of 3111T/C Polymorphism of the Clock Gene with Circadian Rhythm of Melatonin in Menopausal Women with Insomnia.

Bulletin of experimental biology and medicine - 1 Jul 2018

Semenova N V, Madaeva I M, Bairova T A, Zhambalova R M, Kalyuzhnaya O V, Rashidova M A, Kolesnikova L I

Abstract excerpt

We carried out a comparative analysis of circadian rhythms of melatonin secretion in Caucasian menopausal women with and without insomnia depending on the 3111T/C polymorphism of the Clock gene. Melatonin levels was measured in the saliva 4 times a day (06.00-07.00, 12.00-13.00, 18.00-19.00, and 23.00-00.00 h). Carriers of the TT genotype with insomnia demonstrated significantly higher level of melatonin in the...

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PMID: 30003419
DOI: 10.1007/s10517-018-4162-2

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