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Article

Variation in fluoroquinolone pharmacodynamic parameter values among isolates of two bacterial pathogens of bovine respiratory disease.

Scientific reports - 12 Jul 2018

Wen Xuesong, Gehring Ronette, Riviere Jim E, Lubbers Brian V, Gaire Tara Nath, Wyche Bre'Anna, Fox Breanna, Quichocho Victoria, Volkova Victoriya V

Abstract excerpt

To design an antimicrobial treatment regimen for a bacterial disease, data on the drug pharmacodynamics (PD) against selected drug-susceptible strains of the pathogen are used. The regimen is applied across such strains in the field, assuming the PD parameter values remain the same. We used time-kill experiments and PD modeling to investigate the fluoroquinolone enrofloxacin PD against different isolates of two...

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Identifiers

PMID: 30002424
DOI: 10.1038/s41598-018-28602-8
PMCID: PMC6043542

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